Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes.
نویسندگان
چکیده
Strain-promoted cycloadditions of nitrones with cyclooctynes (k(2) = 1.5 M(-1) s(-1) at 25 degrees C) are up to 25 times more rapid than comparable reactions of azides.
منابع مشابه
Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells.
Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes proceed with rate constants up to 3.38 ± 0.31 M(-1) s(-1) in CD(3)CN, or 59 times faster than the analogous reaction of azides. This highly specific modular labeling strategy can be applied for direct labeling of proteins and for live cell imaging of cancer cells.
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عنوان ژورنال:
- Chemical communications
دوره 46 6 شماره
صفحات -
تاریخ انتشار 2010